The Vein Book – Third Edition

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1. Historical Perspective of Venous and Lymphatic Medicine

2. Venous Embryology and Anatomy

• Embryology
  • Chest, Abdomen, and Pelvis
  • Lower Extremity (with Arterial and Neural Embryology)
• Anatomy
  • Abdomen and Pelvis
  • Lower Extremity (with Arterial  and Neural Embryology)

3.  Venous Physiology and Pathophysiology

• Lower Extremity Venous Hemodynamics
• Macrocirculation pathophysiology:
  • Primary Superficial  Insufficiency, Varicose Veins, and Valve Dysfunction
  • Secondary Venous Disease  (Post-Thrombotic Reflux and Obstruction)
  • Primary Deep Vein Reflux
• Microcirculation physiology and  pathophysiology: Understanding Skin Damage and Ulceration

4. Functional Venous Insufficiency

• Obesity and Venous Disease
• Gait Disorders and Venous Insufficiency

5. Genetics of Chronic Venous  Insufficiency

6. Epidemiology of Chronic Venous Disease

• San Diego, Framingham,  Edinburgh, and Bonn Vein Studies

7. Classification of Venous Disease and Clinical Assessment

• Clinical Tools: rCEAP, rVCSS,  PROMs 
• Definitions: Venous reflux,  obstruction and Chronic Venous Insufficiency

8. Cutaneous Manifestations of  Venous Disease: Clinical Considerations and Atlas

9. Compression Therapy

• Devices in Use (GCS, Bandaging, Wraps, Pneumatic and Novel Products)
• Mechanism of Action
• Clinical Applications Overview

10. Venoactive Medications in Chronic Venous and Lymphatic Disease

• Agents in Use
• Mechanism of Action
• Clinical Applications Overview

11. Sclerosing Agents

• Agents in Use
• Mechanism of Action
• Clinical Applications Overview

12. Hematology for the Venous and  Lymphatic Specialist

• Coagulation Cascade in Health and Disease
  • Hypercoagulable Syndromes (Congenital and Acquired)
• Anticoagulants and Antiplatelet Therapies
• Thrombolytic Agents
• Special Populations: Pediatric, Pregnancy, and Oncologic Patients
• Special Considerations:  Thrombotic Risk Assessment and Prophylaxis with Vein Treatment

13. Principles of Venous Ultrasound

14. Techniques, Standards, and Protocols for Venous Ultrasound 

1. Lower Extremities
2. Abdomen, Pelvis

15. Venography: 

1. Lower Limb, 
2. Abdomen and Pelvis
3. Upper extremity and chest

16. Intravascular Ultrasound (IVUS)  in Venous Disease

17. Tools and Techniques for Venous Access

• Cannulation Needles, Wires, Sheaths, Catheters

18. Ultrasound-Guided Cannulation

• Transverse and Longitudinal Techniques, Beam Path, Cannulation Angle

19. Light-Based Therapies for C1 Disease

20. Sclerotherapy for C1-C6

• Visual Sclerotherapy
• Ultrasound-Guided Sclerotherapy
• Management of Trapped Blood

21. Tumescent Anesthesia

22. Micro-Stab Phlebectomy

23. Thermal Ablation of Saphenous  Veins (RF, Laser)

24. Non-Thermal Ablation of Saphenous Veins (MOCA, Glue, Foam)

25. Saphenous sparing hemodynamic strategies: 

1. CHIVA
2. ASVAL

26. Venous Stenting

27. Systemic thrombolysis

28. Venous Thrombectomy and Catheter  Based Thrombolysis 

29. IVC Filters

• Indications
• Devices and Their Use
• Removal

30. Prosthetic Valves and Valvuloplasty

31. Less Used Surgical Approaches

• Saphenous Ligation and Stripping
• Palma Procedure
• May-Husni Procedure

32. Overview of Venous Compressive Disorders

• For each section:
  • Definition and Pathophysiology
  • Common Clinical Presentations

33. Iliac Vein Compression (NIVL, Previously May-Thurner Syndrome)

1. Briefer conversation here as this will be covered in more detail later)

34. Left Renal Vein Compression (Previously Nutcracker Syndrome)

35. Thoracic Outlet Syndrome (With and Without Thrombosis)

36. Popliteal Entrapment Syndrome

37. Other Considerations: Popliteal Aneurysm

38. Superficial Venous Thrombosis (SVT)

39. Acute Distal Lower Extremity Deep Vein Thrombosis (DVT)

1. Tibial
2. Muscular

40. Acute Proximal non-iliofemoral or caval DVT

1. Thrombosis involving the popliteal and femoral veins

41. Acute Iliofemoral and/or IVC DVT

42. Lower Extremity Post-Thrombotic  Sequelae

43. Acute Pulmonary Embolism and its potential chronic consequences

44. Upper Extremity and SVC Acute DVT

45. Overview: Indications, Techniques, Outcomes, and Complications

46. Superficial Venous Disease Management (C1-C2)

1. Telangiectasia and reticular  vein abnormalities (C1)
2. Varicose veins
   1. Non-saphenous varicose veins
   2. Saphenous tributary varicose veins

47. Venous Leg Ulcer Management (C5-C6 Disease)

• Venous Ulcer Care
• Principles
• Techniques
  • Compression Therapy
  • Wound Care
  • Peri-ulcer Skin Care
  • Skin grafts and substitutes
• Superficial Venous Management
• Deep Venous Disease Management
  • Post thrombotic obstruction
    • Sura inguinal
    • Infra inguinal
  • NIVL
  • Infra inguinal Reflux

48. Special Considerations: C4 Venous Skin Disease

49. Special Considerations: Isolated C3 Venous Swelling

1. Include the differential diagnosis of lower limb swelling and when the clinical context suggests a venous etiology

50. Special Considerations: Perforator Vein Disease

51. Special Considerations: Persistent swelling post stenting

52. Overview: Nomenclature, Pathophysiology, and Classification

53. Pelvic Pain Generators in Women

54. Venous-Origin Chronic Pelvic Pain in Women

1. Primary reflux
2. NIVL related
3. Special consideration: co-existent primary reflux and NIVL

55. Lower Extremity Varicose Veins of Pelvic Origin in Women

56. Vulvar Varicose Veins

57. Male Pelvic Venous Disorders

58. General Overview: Historical Background

59. Definition and Classification (ISSVA, Hamburg, Angiographic)

60. Etiopathogenesis: Coagulation Issues

61. Etiopathogenesis: Genetic Issues

62. Contemporary Diagnosis and Management

63. Differential Diagnosis: Hemangioma

64. Extratruncular Lesions: Management and Complications

65. Truncular Lesions: IVC and Iliac-Femoral Vein Dysplasia

66. Special Issues

• Vascular Bone Syndrome
• Klippel-Trenaunay Syndrome
• Marginal Vein
• Biologics and Repurposed Anti-Cancer Drugs in Malformation Treatment
• Multidisciplinary Team Approach

67. General Overview

68. Lymphatic Embryology and Anatomy

69. Etiopathogenesis (Primary and Secondary)

70. Physiology (Phleboedema and Lymphedema)

• Lymphatic Physiology and Pathophysiology: Understanding swelling

71. Clinical Diagnosis and Management      

• Primary Lymphedema
  1. Genetic causes
  2. Idiopathic
• Secondary Lymphedema
  1. Phlebolymphedema
  2. Obesity
  3. Iatrogenic
  4. Other
• Clinical classification of  lymphedema

72. Treatment of lymphedema

• MLD
• Compression
• Exercise
• Skin care

73. Truncular lesions: IVC & Iliac-Femoral Vein dysplasia   

74. Extratruncular Lesions- Management and Their Complications Translational Medicine in  Phlebolymphedema

75. Special Issues 

• Recalcitrant Stasis Ulcer Management
• Lifestyle Considerations

76. Forehead and Periorbital Veinsy

77. Forehead and Periorbital Veins

78. Hand Veins

79. Superficial Venous Practice

80. Deep Venous Practice 

1. Hospital Based
2. OBL/ASC

81. Lymphatic Practice

82. Vascular Malformations Practice

83. Facility Accreditation and Provider Certification

84. Venous Registries: Value of Participation

85. Physician Extender Considerations